Coronary Vasodilator Properties of Purine and Pyrimidine Derivatives

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Coronary vasodilator properties of purine and pyrimidine derivatives.

The vasodilator potency of the adenine nucleotides has been quantitated. Adenosine and AMP were found to be of equal potency and approximately one fourth as effective as ADP and ATP in increasing coronary blood flow. With the exception of UTP, which was also one fourth as potent as ATP, the derivatives of the hypoxanthine, guanine, cytosine and unveil bases lacked vasodilator properties. An inc...

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Pyrimidine Derivatives and Purine Bases in Soils

In earlier papers the presence of protein decomposition products in soils was reported and it was shown that in soils the changes occurring in the decay of such plant and animal materials as get into the soil are similar to the changes occuring under other conditions in the laboratory or in nature. The presence of arginine and histidine in soils was definitely established by isolating these deg...

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Pyrimidine Derivatives and Purine Bases in Soils

In earlier papers the presence of protein decomposition products in soils was reported and it was shown that in soils the changes occurring in the decay of such plant and animal materials as get into the soil are similar to the changes occuring under other conditions in the laboratory or in nature. The presence of arginine and histidine in soils was definitely established by isolating these deg...

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Pyrimidine Derivatives and Purine Bases in Soils

In earlier papers the presence of protein decomposition products in soils was reported and it was shown that in soils the changes occurring in the decay of such plant and animal materials as get into the soil are similar to the changes occuring under other conditions in the laboratory or in nature. The presence of arginine and histidine in soils was definitely established by isolating these deg...

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Synthesis and antibacterial properties of pyrimidine derivatives.

In this study, a series of syntheses was conducted on the pyrimidine system, obtaining bisulfite carboxyl derivatives 4 and hydroxy derivatives 5. In addition, a series of syntheses were carried out as a result of which both alkyl and aromatic amines were obtained. Then, the attempt was made to cyclize these amines in the Mannich reaction to pyrimido[4,5-d]pyrimidines 11, 12. After determinatio...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1956

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.4.3.343